Immunological crossreaction between alpha-fetoprotein and albumin.
نویسندگان
چکیده
منابع مشابه
Amino acid sequence homology between rat alpha-fetoprotein and albumin at the COOH-terminal regions.
The nucleotide sequence of the 3'-terminal untranslated region and a portion of the coding region of rat alpha-fetoprotein mRNA has been determined from a cloned double-stranded cDNA. the amino acid sequence of the COOH-terminal portion of alpha-fetoprotein was inferred from the nucleotide sequence and compared to the amino acid sequence of the corresponding portion of rat, bovine, and human al...
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Alpha-fetoprotein (AFP), a serum glycoprotein belonging to the onco-developmental proteins group, serves as a marker both in cancer research and in studies concerning fetal development and fetal pathophysiology. Monoclonal anti-AFP antibodies are essential reagents in developing appropriate techniques for measurement of this protein. In this study, in order to produce anti-AFP monoclonal a...
متن کاملEvolutionary and structural relationships among the group-specific component, albumin and alpha-fetoprotein.
The group-specific component (Gc) is a plasma protein that binds vitamin D. Recent characterization of human Gc cDNA demonstrated homology with serum albumin and alpha-fetoprotein. This study compares the sequences of the three proteins and demonstrates a strong evolutionary relationship. Albumin, alpha-fetoprotein and Gc evolved from an ancestral gene containing an intragenic triplication. Com...
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Cytology in General Practice H. C. McLaren, F.R.C.O.G..... 350 Chronic Prostatitis Surgeon Commander N. J. Blacklock, F.R.C.S., and D. S. Reeves, M.R.C.PATH. 351 Trapped Nerves W. V. Applegate, M.D............................351 Distress of Dying R. C. Lamerton, M.R.C.S......................351 Alpha-fetoprotein and Gastric Carcinoma C. M. Castleden, M.R.C.P., and J. D. Davies, M.D . .............
متن کاملalpha-Fetoprotein and albumin genes are in tandem in the mouse genome.
The urine alpha-fetoprotein (AFP) and serum albumin genes most probably arose in evolution as the consequence of a duplication of a common ancestral gene. They have both been previously mapped to chromosome 5 in the mouse. We now have evidence that these genes are closely linked. By using a unique copy DNA probe derived from previously cloned AFP 5' flanking DNA, a recombinant DNA phage has bee...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1976
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.73.12.4641